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Abstract
The aging skin microenvironment is characterized by six interconnected components that contribute to skin aging.
- Cellular senescence and immune cell dysfunction lead to increased inflammation in the skin.
- Dysregulation of the extracellular matrix contributes to structural degradation.
- Defects in intercellular communication and extracellular vesicles may impair skin function.
- Changes in the physical microenvironment can further exacerbate skin aging.
- Stem cell exhaustion is associated with a decline in regenerative capacity.
- Microbiome dysbiosis is linked to the overall aging process of the skin.
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