Senescence as a molecular target in skin aging and disease

Cellular senescence may drive physiological and pathological skin aging.

• Skin aging is influenced by a combination of intrinsic and extrinsic factors, termed the skin exposome.
• Senescence is characterized by stable cell cycle arrest and the release of inflammatory molecules.
• Accumulation of senescent cells in the skin may worsen various dermatological diseases.
• Therapeutic strategies like senolytics and senomorphics could target senescent cells to reduce their harmful effects.
• The review discusses molecular mechanisms of senescence and the potential of senotherapeutics to address age-related skin changes.

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