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Abstract
Cellular senescence may drive physiological and pathological skin aging.
- Skin aging is influenced by a combination of intrinsic and extrinsic factors, termed the skin exposome.
- Senescence is characterized by stable cell cycle arrest and the release of inflammatory molecules.
- Accumulation of senescent cells in the skin may worsen various dermatological diseases.
- Therapeutic strategies like senolytics and senomorphics could target senescent cells to reduce their harmful effects.
- The review discusses molecular mechanisms of senescence and the potential of senotherapeutics to address age-related skin changes.
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