It is unknown whether air pollution is associated with radiographic features of interstitial lung disease in individuals with chronic obstructive pulmonary disease (COPD).To determine whether air pollution increases the prevalence of interstitial lung abnormalities (ILA) or percent high-attenuation areas (HAA) on computed tomography (CT) in individuals with a heavy smoking history and COPD.We performed a cross-sectional study of SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study), focused on current or former smokers with COPD. Ten-year exposure to particulate matter ⩽2.5 μm in aerodynamic diameter (PM), nitrogen oxides (NO), nitrogen dioxide (NO), and ozone before enrollment CT (completed between 2010 and 2015) were estimated with validated spatiotemporal models at residential addresses. We applied adjusted multivariable modified Poisson regression and linear regression to investigate associations between pollution exposure and relative risk (RR) of ILA or increased percent HAA (between -600 and -250 Hounsfield units), respectively. We assessed for effect modification by-promoter polymorphism (variant allele carriers GT or TT vs. GG at rs3705950), smoking status, sex, and percent emphysema.Among 1,272 participants with COPD assessed for HAA, 424 were current smokers, and 249 were carriers of the variantallele. A total of 519 participants were assessed for ILA. We found no association between pollution exposure and ILA or HAA. Associations between pollutant exposures and risk of ILA were modified by the presence ofpolymorphism (value interaction term for NO = 0.04 and PM = 0.05) and smoking status (value interaction term for NO = 0.05; NO = 0.01; and ozone = 0.05). With higher exposure to NOand PM,variant carriers had an increased risk of ILA (RR per 26 ppb NO, 2.41; 95% confidence interval [CI], 0.97-6.0; and RR per 4 μg ⋅ mPM, 1.43; 95% CI, 0.93-2.2, respectively). With higher exposure to NO, former smokers had an increased risk of ILA (RR per 10 ppb, 1.64; 95% CI, 1.0-2.7).Exposure to ambient air pollution was not associated with interstitial features on CT in this population of heavy smokers with COPD.modified the association between pollution and ILA, suggesting that gene-environment interactions may influence prevalence of interstitial lung features in COPD. Rationale: Objectives: Methods: Results: Conclusions: 2.5x2x2.5x2x2.5x2.5 2MUC5B MUC5B MUC5B P P MUC5B MUC5B -3
