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Abstract
Air pollution may negatively affect the brain and contribute to central nervous system diseases.
- Air pollution includes various components like particulate matter, gases, organic compounds, and metals.
- Traffic-related air pollution, primarily from diesel exhaust, is a significant contributor to harmful effects on the brain.
- Exposure to air pollution is associated with oxidative stress and neuro-inflammation, observed in both humans and animals.
- Age may influence the neurotoxic outcomes of air pollution exposure.
- Air pollution may lead to developmental neurotoxicity and is linked to neurodevelopmental disorders, such as autism spectrum disorder.
- Increased levels of neurodegenerative disease markers, like alpha-synuclein and beta-amyloid, are associated with exposure to air pollution.
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