Associations of alcohol consumption with blood pressure, lipoproteins, and subclinical inflammation among Turks

Oct 7, 2008Alcohol (Fayetteville, N.Y.)

Links between alcohol drinking and blood pressure, cholesterol, and low-level inflammation in Turkish people

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Abstract

Among 3,443 participants followed for a mean of 7.4 years, heavy drinking was positively associated with blood pressure and low-density lipoprotein cholesterol in men.

Men showed a significant increase in low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) levels with heavier alcohol consumption.
Women exhibited a decline in triglycerides with light-to-moderate alcohol intake, contrasting with men who showed an increase.
Lower blood pressure and CRP levels were found in female drinkers compared to abstainers.
Heavy drinking was associated with a reduced risk of low high-density lipoprotein cholesterol levels in both sexes.
Sex differences were evident, with men experiencing adverse cardiometabolic effects from alcohol consumption that were not observed in women.

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Gender-related impact of alcohol consumption on blood pressure (BP), serum lipoprotein profile, and C-reactive protein (CRP) concentrations was evaluated prospectively. Alcohol drinking status was assessed as abstainers and categories of light, moderate, and heavy (daily >40 ml ethanol) intake. Mean age of the 3,443 men and women who were followed up for a mean of 7.4 years was 47.6+/-12 years. In each multivariable linear or logistic regression analysis, alcohol drinking status was adjusted for age, sex, smoking status, and physical activity. Among men, drinking was significantly associated positively with low-density lipo protein (LDL) cholesterol, apolipoprotein (apo) B, systolic and diastolic BP, and with CRP in a log-linear manner exhibiting features of a threshold at heavy drinking. With respect to response of serum triglycerides to light-to-moderate drinking, whereas men exhibited a significant increase, women exhibited a decline (P<.05). Lower BPs (P<.03) and CRP levels (P=.032) were observed in female drinkers than abstainers and, as distinct from men, no increases in LDL cholesterol and apoB were noted. Heavy drinking tended to protect the sexes against the risk of developing low high-density lipoprotein cholesterol levels in prospective multi adjusted analyses. Sex modulates response of cardiometabolic risk variables to moderate alcohol consumption among Turks. Only women respond with lower triglycerides and CRP, whereas men show a log-linear positive association of drinking categories with BP, LDL cholesterol, apoB, and CRP.

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Associations of alcohol consumption with blood pressure, lipoproteins, and subclinical inflammation among Turks

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