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Abstract
Mice lacking the α2δ-1 protein in specific neurons show glucose intolerance and altered lipid metabolism.
- α2δ-1 regulates glucose and lipid balance in steroidogenic factor-1 (SF1) neurons of the ventromedial hypothalamus.
- Deletions of α2δ-1 in SF1 neurons lead to decreased sympathetic output to metabolic tissues.
- Alterations in metabolic parameters occur despite normal body weight regulation.
- Changes include reduced firing rates of SF1 neurons and elevated levels of serotonin in circulation.
- Normal calcium currents but reduced excitatory signals in mutant SF1 neurons suggest a role for α2δ-1 beyond calcium channel function.
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