Altered circadian activity and sleep/wake rhythms in the stable tubule only polypeptide (STOP) null mouse model of schizophrenia

STOP knockout (KO) mice spent more time awake and less time in non-rapid eye movement sleep (NREMS) compared to wild-type mice.

• STOP KO mice exhibited lower activity levels and more fragmented activity compared to wild-type mice under both light/dark and constant darkness conditions.
• Both KO and wild-type mice displayed similar wheel-running activity rhythms in light/dark cycles and free-running periods in constant darkness.
• KO mice had less stable activity onsets and lower amplitude activity rhythms than wild-type mice.
• The phase delay response to a light pulse in KO mice was preserved, indicating intact circadian mechanisms.
• Altered EEG features were observed in KO mice, including higher amplitude rhythms in wake and NREMS but not in REMS.

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