Altered diurnal variation and localization of clock proteins in the remnant kidney of 5/6 nephrectomy rats

Clock proteins in the remnant kidney of 5/6 nephrectomy rats show altered expression and localization.

• Clock proteins (BMAL1, PER2, DBP) exhibit diurnal rhythms in control rats but show changes in STNx rats.
• The timing (acrophase) of BMAL1, DBP, and PER2 expression advanced by 4 hours in STNx rats.
• The average level (mesor) of clock proteins increased in STNx rats compared to controls.
• BMAL1 is found in endothelial cells of glomeruli and tubular cells in both the cortex and medulla.
• PER2 is primarily expressed in proximal tubular cells at the boundary of the cortex and medulla.
• The distribution of BMAL1 and PER2 is altered in the kidneys of STNx rats.

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