Nephrology (Carlton, Vic.)

Changes in daily patterns and location of body clock proteins in damaged kidneys of rats after major kidney removal

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Updated

Abstract

Clock proteins in the remnant kidney of 5/6 nephrectomy rats show altered expression and localization.

  • Clock proteins (BMAL1, PER2, DBP) exhibit diurnal rhythms in control rats but show changes in STNx rats.
  • The timing (acrophase) of BMAL1, DBP, and PER2 expression advanced by 4 hours in STNx rats.
  • The average level (mesor) of clock proteins increased in STNx rats compared to controls.
  • BMAL1 is found in endothelial cells of glomeruli and tubular cells in both the cortex and medulla.
  • PER2 is primarily expressed in proximal tubular cells at the boundary of the cortex and medulla.
  • The distribution of BMAL1 and PER2 is altered in the kidneys of STNx rats.

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