Rhythmic clock gene expression in heart, kidney and some brain nuclei involved in blood pressure control in hypertensive TGR(mREN-2)27 rats

Aug 16, 2006Molecular and cellular biochemistry

Daily rhythms of clock gene activity in the heart, kidney, and blood pressure control brain areas of high blood pressure rats

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Abstract

Blood pressure and relative heart weight were significantly elevated in TGR rats compared to control.

  • Expression of the clock genes bmal1 and clock was increased in the suprachiasmatic nucleus (SCN) of TGR rats.
  • Daily rhythm patterns for per2 and dbp expression were similar in both TGR and control rats.
  • Mesor (mean level) of per2 expression in the rostral ventrolateral medulla (RVLM) was significantly higher in TGR rats.
  • In the nucleus of the solitary tract (NTS), per2 expression in TGR rats was phase delayed by 3.5 hours compared to control rats.
  • Bmal1 did not show a rhythmic pattern in the NTS of TGR rats.
  • Circadian oscillators in specific brain regions were more affected than those in the heart and kidney by the additional renin gene.

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