Altered Expression of Circadian Clock Genes in Human Chronic Myeloid Leukemia

Disrupted daily patterns of circadian clock gene expression may be associated with chronic myeloid leukemia (CML).

• Expression profiles of 9 circadian clock genes were compared in blood cells from 18 healthy volunteers.
• All 9 circadian clock genes displayed similar expression patterns in healthy individuals' blood cells.
• In healthy individuals, expression levels of six genes peaked at 0800 h, while another peaked at 2000 h.
• Newly diagnosed CML patients showed disrupted daily expression patterns of these six genes.
• Partial recoveries of daily expression patterns were noted in CML patients achieving complete cytogenetic response.
• The expression of CLOCK and TIM did not vary with time in either healthy individuals or CML patients.

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