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Altered metabolic and hormonal responses in male rats exposed to acute bright light-at-night associated with global DNA hypo-methylation
Changes in metabolism and hormones linked to DNA changes in male rats exposed to bright light at night
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Abstract
Mass gain was higher in artificial light at night (ALAN) rats compared with controls.
- Artificial light at night is associated with reduced food and water intake, serum glucose, insulin, and melatonin levels.
- Increased urine production and elevated body temperature were observed in ALAN rats compared to controls.
- Daily rhythms of multiple physiological parameters were disrupted under ALAN conditions, affecting their patterns and timing.
- DNA hypo-methylation occurred in pancreatic tissue of ALAN rats, suggesting potential epigenetic changes.
- The findings indicate a complex relationship between light exposure, metabolic processes, and hormonal regulation.
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