The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice

APP/PS1 mice crossed with Ames dwarf mice showed reduced Aβ plaque deposition and decreased gliosis at 6 months of age.

• APP/PS1 mice develop brain amyloid plaques, oxidative stress, behavioral dysfunction, and proinflammatory gliosis.
• Ames dwarf mice, lacking certain hormones, exhibit enhanced antioxidant mechanisms, improved cognitive function, and increased lifespan.
• Crossbreeding APP/PS1 mice with Ames dwarf mice led to lower concentrations of brain growth hormone and insulin-like growth factor 1.
• The df/df/APP/PS1 mice exhibited decreased astrogliosis and microgliosis, alongside reduced Aβ 1-40 and Aβ 1-42 concentrations.
• Elevated levels of multiple brain cytokines were observed in df/df/APP/PS1 mice, despite the reduction in gliosis.

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