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AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy
AMPK works with Sestrins to help exercise improve insulin sensitivity by boosting cell cleanup
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Abstract
A single bout of exercise increased autophagy activity in skeletal muscle of wild type mice but not in AMPKα2(-/-) mice.
- Autophagy is linked to enhanced glucose uptake in skeletal muscle.
- Long-term exercise raised the basal level of muscle autophagy and Sestrin protein expression.
- In wild type mice, exercise triggered the coimmunoprecipitation of Sestrin2 and Sestrin3 with AMPKα2.
- The findings suggest that the interaction between exercise-induced AMPK and Sestrins may play a role in the metabolic benefits of exercise.
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