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Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus
Amylin Specifically Sends Signals to Appetite-Control Neurons in the Brain’s Arcuate Nucleus
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Abstract
Amylin phosphorylates ERK in the area postrema, which may reduce food intake and body weight.
- In amylin knockout mice, the density of agouti-related protein (AgRP)-immunoreactive fibers in the hypothalamic paraventricular nucleus was increased.
- The density of α-melanocyte-stimulating hormone (αMSH) fibers was decreased in the same amylin knockout mice.
- Mice lacking amylin receptor components RAMP1/3 showed decreased densities of both AgRP and αMSH-immunoreactive fibers.
- Neonatally injected rats with a virus targeting the amylin core receptor exhibited a decrease only in αMSH fiber density.
- Amylin induced ERK phosphorylation in ARC neurons, with 60% occurring in POMC-expressing neurons and none in NPY neurons.
- An additive effect of amylin and leptin on ARC ERK signaling was observed in neonatal rats.
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