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Differential effects of amylin and salmon calcitonin on neuropeptide gene expression in the lateral hypothalamic area and the arcuate nucleus of the rat
Different effects of amylin and salmon calcitonin on nerve-signaling gene activity in two appetite control areas of the rat brain
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Abstract
Intraperitoneal injection of amylin (50 microgram/kg) or salmon calcitonin (50 microgram/kg) reduced orexin mRNA levels in the lateral hypothalamic area (LHA) of rats.
- Both amylin and salmon calcitonin decreased orexin mRNA levels, indicating a potential mechanism for reduced food intake.
- Salmon calcitonin also significantly suppressed levels of melanin concentrating hormone in the LHA.
- Other orexigenic neuropeptides, including neuropeptide Y and proopiomelanocortin, showed no significant changes after treatment.
- The findings suggest that the anorexigenic effects of amylin and salmon calcitonin may involve reduced expression of specific neuropeptides in the LHA.
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