Different effects of amylin and salmon calcitonin on nerve-signaling gene activity in two appetite control areas of the rat brain

Intraperitoneal injection of amylin (50 microgram/kg) or salmon calcitonin (50 microgram/kg) reduced orexin mRNA levels in the lateral hypothalamic area (LHA) of rats.

• Both amylin and salmon calcitonin decreased orexin mRNA levels, indicating a potential mechanism for reduced food intake.
• Salmon calcitonin also significantly suppressed levels of melanin concentrating hormone in the LHA.
• Other orexigenic neuropeptides, including neuropeptide Y and proopiomelanocortin, showed no significant changes after treatment.
• The findings suggest that the anorexigenic effects of amylin and salmon calcitonin may involve reduced expression of specific neuropeptides in the LHA.

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