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Neuropeptide Y, but Not Agouti-Related Peptide or Melanin-Concentrating Hormone, Is a Target Peptide for Orexin-A Feeding Actions in the Rat Hypothalamus
Orexin-A affects feeding by targeting neuropeptide Y but not agouti-related peptide or melanin-concentrating hormone in the rat feeding control area
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Abstract
A single dose of orexin A (3 nmol) increased neuropeptide Y expression in the arcuate nucleus of the rat hypothalamus at 2 hours post-treatment.
- The increase in neuropeptide Y expression was transient, observed only at 2 hours after treatment.
- No changes were observed in hypothalamic levels of agouti-related peptide, melanin-concentrating hormone, prepro-orexin, or orexin receptors at any time point.
- The findings suggest that neuropeptide Y may play a role in orexin-induced feeding behavior.
- Orexins could also be linked to other functions such as locomotor activity and sympathetic function.
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