Full text is available at the source.
Orexin-A affects feeding by targeting neuropeptide Y but not agouti-related peptide or melanin-concentrating hormone in the rat feeding control area
Updated
Abstract
A single dose of orexin A (3 nmol) increased neuropeptide Y expression in the arcuate nucleus of the rat hypothalamus at 2 hours post-treatment.
- The increase in neuropeptide Y expression was transient, observed only at 2 hours after treatment.
- No changes were observed in hypothalamic levels of agouti-related peptide, melanin-concentrating hormone, prepro-orexin, or orexin receptors at any time point.
- The findings suggest that neuropeptide Y may play a role in orexin-induced feeding behavior.
- Orexins could also be linked to other functions such as locomotor activity and sympathetic function.
Simplified