How the body’s internal clock controls amyloid-beta levels and related brain changes

Loss of central circadian rhythms leads to disrupted daily fluctuations in amyloid-β and accelerates plaque accumulation in a mouse model of Alzheimer's Disease.

• Disrupted circadian clock function is associated with altered levels of amyloid-β in the brain.
• Accelerated accumulation of amyloid plaques occurs with the loss of central circadian rhythms.
• Local disruption of circadian function increases expression of factors that promote plaque deposition.
• Findings suggest that both central and local circadian mechanisms may influence Alzheimer's Disease progression.

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