An Insight into the Synthesis and SAR of 2,4-Thiazolidinediones (2,4-TZD) as Multifunctional Scaffold: A Review

2,4-Thiazolidinedione (2,4-TZD) is associated with diverse pharmacological activities.

• Various mechanisms of action contribute to the multifaceted biological activities of 2,4-TZD.
• Recent developments have focused on creating new potential molecules that incorporate 2,4-TZD.
• Structure-activity relationships (SAR) have been analyzed to understand the therapeutic potential of 2,4-TZD derivatives.
• The review illustrates active pharmacophores linked to antidiabetic, anticancer, antimicrobial, and antioxidant activities.
• Important chemical synthetic routes for producing various 2,4-TZD derivatives are highlighted.

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