How blocking angiotensin II receptors and exercise training affect insulin response in rats fed a high-fat diet

Combined treatment with candesartan cilexetil and exercise significantly improved glucose tolerance in high-fat diet-fed rats.

• Oral glucose tolerance tests indicated better glucose tolerance with the combination treatment compared to each treatment alone.
• Exercise training and candesartan cilexetil alone improved glucose infusion rates, with the combination showing further enhancement.
• Systolic blood pressure improved with candesartan cilexetil, while exercise alone did not affect it.
• High-fat diet reduced Glut-4 protein levels in soleus muscle, but exercise increased these levels, unlike candesartan cilexetil.

Simplified