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Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet
How blocking angiotensin II receptors and exercise training affect insulin response in rats fed a high-fat diet
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Abstract
Combined treatment with candesartan cilexetil and exercise significantly improved glucose tolerance in high-fat diet-fed rats.
- Oral glucose tolerance tests indicated better glucose tolerance with the combination treatment compared to each treatment alone.
- Exercise training and candesartan cilexetil alone improved glucose infusion rates, with the combination showing further enhancement.
- Systolic blood pressure improved with candesartan cilexetil, while exercise alone did not affect it.
- High-fat diet reduced Glut-4 protein levels in soleus muscle, but exercise increased these levels, unlike candesartan cilexetil.
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