Anisotropic Tussah Silk Nanofiber Scaffolds for Accelerating Wound Repair

Oct 17, 2025ACS applied bio materials

Directionally Arranged Tussah Silk Nanofiber Scaffolds to Speed Up Wound Healing

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

The radial scaffolds achieved a 99.8 ± 0.1% healing rate in wound repair after 14 days.

Anisotropic tussah silk nanofiber scaffolds were designed to enhance cell adhesion, migration, and tissue growth.
In vitro studies showed that radial and aligned structures increased fibroblast proliferation and directional migration.
In vivo results indicated that radial scaffolds facilitated superior growth of blood vessels and tissues.
Positive expression rates for blood vessel markers CD31 and α-SMA were 13.0 ± 1.1% and 18.8 ± 0.8%, respectively.
Collagen deposition rate was measured at 71.2 ± 3.5% in the radial scaffolds after implantation.

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Scaffolds with anisotropic structures are attractive for wound repair due to their enhanced ability to promote cell adhesion, migration, and tissue growth. In this study, anisotropic tussah silk nanofiber (TSn) scaffolds were developed through physical shearing, NaOH hydrolysis, and ice templating to accelerate wound healing. The anisotropic TSn scaffolds demonstrated radial and aligned structures, which would influence cell behavior and tissue regeneration. In vitro cellular studies have demonstrated that radial and aligned structures promoted fibroblast proliferation and directional migration. Furthermore, the disordered scaffolds (DS), aligned scaffolds (AS), and radial scaffolds (RS) were investigated to elucidate the effect of the different structures on wound healing. In vivo results demonstrated that the RS (99.8 ± 0.1%) exhibited the fastest healing rate, which may be attributed to the enhanced peripheral to central growth of blood vessels (the positive expression rates of CD31 and α-SMA were 13.0 ± 1.1% and 18.8 ± 0.8%, respectively) and tissues (the collagen deposition rate was 71.2 ± 3.5%) 14 days post implantation under the guidance of its radial structure. Taken together, biomimetic TSn scaffolds with radial structures performed the best in wound healing, offering promising applications in skin wound healing.

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Anisotropic Tussah Silk Nanofiber Scaffolds for Accelerating Wound Repair

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