A radially aligned nanofiber scaffold with engineered guidance gradients for directed cell migration and accelerated wound healing

The graded nanofiber scaffold promotes skin repair by integrating multiple cues for cell guidance.

• The scaffold combines topographic, haptotactic, and chemotactic signals to facilitate skin wound healing.
• Sustained release of epidermal growth factor (EGF) occurs for up to 10 days, supporting cell migration toward the wound center.
• In vitro tests show improved directional migration and proliferation of skin cells, specifically keratinocytes and fibroblasts.
• Transcriptomic analysis indicates activation of pathways related to cell movement and adhesion processes.
• In a rat skin injury model, the scaffold led to faster wound closure, increased cell proliferation, and more collagen deposition.

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