Timed release of healing molecules from tiny fiber scaffolds speeds up skin wound healing in pigs

A nanofiber scaffold enhanced skin wound closure in a preclinical porcine model.

• The scaffold was designed with two outer layers of aligned and random fibers and a middle layer containing growth factors.
• Controlled release of PDGF-BB, VEGF, and EGF was achieved using near-infrared irradiation, timed to match wound healing phases.
• Activation of pathways associated with cell survival and tissue repair was observed, along with a reduction in inflammation and apoptosis-related genes.
• The scaffold demonstrated potential for scalable manufacturing and effective application in large animal models.

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