Ginsenoside Rg1's potential to reduce aging in repeated blood stem cell transplants
Updated
Abstract
The 30-day survival rate of female recipient mice decreased with serial transplantation of hematopoietic stem cells.
- Hematopoietic reconstruction cells in recipient mice originated from male donor mice.
- Aging characteristics were observed in Sca-1 (+) HSC/HPC, including increased G0/G1 phase cell ratio and SA-beta-gal staining positivity.
- Treatment with ginsenoside Rg1 resulted in higher survival rates and improved blood cell counts compared to aging controls.
- The Rg1 anti-aging group exhibited more significant improvements than the Rg1-treated aging group.
- Rg1 may delay and treat aging in Sca-1 (+) HSC/HPC during serial transplantation.
Simplified