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Ginsenoside Rg1 Performs Anti-Aging Functions by Suppressing Mitochondrial Pathway-Mediated Apoptosis and Activating Sirtuin 3 (SIRT3)/Superoxide Dismutase 2 (SOD2) Pathway in Sca-1⁺ HSC/HPC Cells of an Aging Rat Model
Ginsenoside Rg1 may slow aging by reducing cell death and boosting protective enzymes in blood-forming stem cells of aging rats
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Abstract
Rg1 treatment significantly decreased SA-ß-Gal-positive staining in Sca-1⁺ HSC/HPC cells compared to the D-gal model (p<0.05).
- Rg1 treatment and prevention improved the formation capacity of CFU-Mix in Sca-1⁺ HSC/HPC cells compared to the D-gal model (p<0.05).
- Rg1 significantly reduced the proportion of Sca-1⁺ HSC/HPC cells in the G0/G1 phase compared to the D-gal model (p<0.05).
- Rg1 decreased the expression of cleaved caspase 3 and Bax, while increasing Bcl-2 expression compared to the D-gal model (p<0.05).
- Rg1 treatment upregulated the expressions of SIRT3 and SOD2 in Sca-1⁺ HSC/HPC cells compared to the D-gal model (p<0.05).
- Rg1 may exert anti-aging effects by inhibiting a specific type of cell death and activating certain protective cellular pathways.
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