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Anti-skin aging effects of black ginseng extracts through regulating inflammatory factors and the CLOCK–ERK pathway in mice
Black ginseng extracts may reduce skin aging in mice by controlling inflammation and internal body clock signals
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Abstract
Rg3, an active ingredient in black ginseng extract, decreased the expression of key aging-related markers in aging mice.
- Black ginseng extract may enhance antioxidant capacity in aging cells.
- Treatment with Rg3 led to reduced levels of β-galactosidase and decreased mRNA levels of p16, p21, TNF-α, and IL-1β.
- The TNF signaling pathway is potentially involved in the anti-skin aging effects of black ginseng and Polygala tenuifolia.
- Black ginseng and Polygala tenuifolia may reverse alterations in IL-1β, TNF-α, clock genes, and p-ERK1/2 in aged mice.
- The extracts could inhibit oxidative stress and inflammation, affecting clock gene regulation and epidermal stem cell differentiation.
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