The Journal of clinical psychiatryJan 14, 2000

Current antidepressants used to treat anxiety disorders

Psychedelic Science Weekly Brief ↗PubMed ↗

Updated Mar 28, 2026

Abstract

Tertiary tricyclic antidepressants (TCAs) may be consistently effective across anxiety disorders.

Anxiety and depression may be separate but overlapping disorders.
Antidepressants are effective treatments for both anxiety and comorbid anxiety-depression.
Selective serotonin reuptake inhibitors (SSRIs) show particular efficacy in panic disorder and obsessive-compulsive disorder.
SSRIs have similar effectiveness to TCAs but are better tolerated with fewer serious side effects.
Efficacy data for SSRIs in generalized anxiety disorder is limited.
Newer antidepressants like mirtazapine, nefazodone, and venlafaxine XR could offer benefits across various anxiety disorders.

Simplified

The syndromes of anxiety and depression may reflect separate disorders with overlapping symptoms. They also may be comorbid or reflect illnesses with similar underlying pathophysiology based upon a spectrum of central nervous system dysfunction. Antidepressants effectively treat both anxiety and comorbid anxiety-depression. Tertiary tricyclic antidepressant agents (TCAs) with dual serotonergic-noradrenergic effects, such as imipramine and amitriptyline, appear consistently effective across the anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) are particularly effective in panic disorder and obsessive-compulsive disorder. SSRIs are similar in efficacy to TCAs but are more tolerable and cause fewer serious adverse events. However, they are relatively slow to act, and efficacy data are limited in states such as generalized anxiety disorder. Newer antidepressants, such as mirtazapine, nefazodone, and venlafaxine XR, may provide some benefits across the broad spectrum of anxiety disorders with the safety and tolerability that are the hallmarks of third generation antidepressants.

Current antidepressants used to treat anxiety disorders

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