Antiphase Circadian Expression betweenBMAL1andperiodHomologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats

Jan 8, 1999Biochemical and biophysical research communications

Opposite daily patterns of two key clock genes in the brain’s timekeeping center and body tissues of rats

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Abstract

Circadian expression of BMAL1 mRNA peaks at the time of dark-light transition in the suprachiasmatic nucleus.

  • BMAL1 mRNA exhibits a circadian expression pattern in the suprachiasmatic nucleus (SCN) that is out of phase with rPer1 and rPer2.
  • No circadian oscillation for rat Clock mRNA was detected in this study.
  • BMAL1 mRNA also shows circadian expression in peripheral tissues, including brain (excluding the SCN), eye, heart, kidney, and lung.
  • The expression levels of BMAL1 and rPer2 mRNA are correlated across different tissues.
  • The findings suggest that BMAL1 mRNA may play a significant role in regulating the circadian expression of per homologue genes in mammals.

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