Recent advances in antituberculous drug development and novel drug targets

May 19, 2010Expert review of respiratory medicine

New developments and targets for tuberculosis medicines

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Abstract

Advances in understanding Mycobacterium tuberculosis may aid in the development of new anti-tuberculous drugs.

  • Critical information on the entire genome of Mycobacterium tuberculosis has been elucidated.
  • Knowledge of various mycobacterial virulence genes may enhance the identification of new drug targets.
  • Potential pharmacological targets for future anti-tuberculous drug development include specific genes related to MTB.
  • Promising new anti-tuberculous agents under development include nitroimidazoles, diarylquinolines, and oxazolidinones.

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