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Abstract
CRISPR-Cas9 gene editing technology may offer transformative hope for treating hereditary liver diseases.
- Inherited liver diseases are mostly caused by single-gene mutations.
- Current treatment options for these conditions are largely non-curative.
- Liver transplantation is complicated by organ shortages, immune rejection, and lifelong medication requirements.
- Recent advancements in CRISPR-Cas9 technology could improve treatment strategies for these diseases.
- The review outlines the principles and benefits of CRISPR-Cas9 and its advanced forms, including base and prime editing.
- Challenges remain for the clinical application of these gene editing technologies.
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