The Arabidopsis LDL1/2-HDA6 histone modification complex is functionally associated with CCA1/LHY in regulation of circadian clock genes

Aug 21, 2018Nucleic acids research

A plant protein complex works with key clock proteins to regulate daily rhythm genes

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Abstract

Lysine-Specific Demethylase 1 (LSD1)-like histone demethylases LDL1 and LDL2 repress the expression of TOC1 in Arabidopsis.

  • CCA1 and LHY, expressed in the morning, negatively regulate TOC1, which is expressed in the evening.
  • TOC1 binds to the promoters of CCA1 and LHY, further repressing their expression.
  • Histone modifications are suggested to play a significant role in regulating the central oscillators of the .
  • ChIP-Seq analysis shows that LDL1 targets genes related to the circadian rhythm controlled by CCA1.
  • LDL1 and LDL2 interact with the histone deacetylase HDA6, influencing TOC1 regulation through histone demethylation and deacetylation.

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