Artificial intelligence empowers gut microbiota research in neurodegenerative diseases molecular mechanisms and precision therapy

Dec 17, 2025iScience

How Artificial Intelligence Advances Research on Gut Bacteria's Role in Brain Diseases and Targeted Treatments

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Abstract

The paper reviews the role of gut microbiota in neurodegenerative diseases (NDs) and the potential applications of AI in this research area.

Neurodegenerative diseases are influenced by genetic, environmental, and metabolic factors.
The gut microbiota may play a significant role in the health of the nervous system.
Current research highlights the importance of the gut-brain axis in understanding NDs.
AI technology offers new tools for modeling and analyzing complex biological systems related to NDs.
The review suggests new ideas for exploring the molecular mechanisms and treatments for NDs.

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Neurodegenerative diseases (NDs) are a type of chronic and complex diseases that seriously affect the quality of human life. Their pathogenesis involves aspects such as genetics, environment, and metabolism. In recent years, the close relationship between gut microbiota and host health has gradually attracted attention, especially with the promotion of the concept of "gut-brain axis," and the role of gut microbiota in nervous system diseases has become a research focus. At the same time, the rapid development of AI technology has provided powerful tools for modeling and data analysis of complex biological systems. This paper reviews the molecular mechanism and therapeutic approaches of gut microbiota in NDs and discusses the application potential of AI in this field, aiming to provide new ideas for the molecular mechanism research and precise treatment of NDs.

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Artificial intelligence empowers gut microbiota research in neurodegenerative diseases molecular mechanisms and precision therapy

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