Artificial Light at Night (ALAN) and breast cancer incidence worldwide: A revisit of earlier findings with analysis of current trends

Jun 24, 2015Chronobiology international

Artificial Light at Night and Worldwide Breast Cancer Rates: Updated Analysis of Recent Trends

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Abstract

The association between breast cancer incidence and artificial light at night may have weakened from 2002 to 2012 in a global analysis of 180 countries.

Breast cancer incidence was significantly associated with artificial light at night (ALAN) in 2002 but became statistically insignificant by 2012 after controlling for confounding factors.
In geographic clusters of similarly developed countries, a positive association between breast cancer and ALAN re-emerged as statistically significant in 2012.
About 65-85% of the variability in age-standardized breast cancer rates worldwide could be explained by the ALAN association and other factors analyzed.
Regional differences were observed, with Western Europe showing the highest association while Southeast Asia and Gulf States had relatively low breast cancer rates despite high ALAN levels.
The variation in breast cancer rates may be influenced by additional protective mechanisms linked to local diets and lifestyles.

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In a study published in Cancer Causes & Control in 2010, Kloog with co-authors tested, apparently for the first time, the association between population-level ambient exposure to artificial light at night (ALAN) and incidence of several cancers in women from 164 countries worldwide. The study was based on 1996-2002 data and concluded that breast cancer (BC) incidence was significantly and positively associated with ALAN, while no such association was revealed for other cancer types. An open question, however, remains whether the trends revealed by Kloog and co-authors were time specific or also hold true for more recent data. Using information obtained from the GLOBOCAN, US-DMSP and World Bank's 2002 and 2012 databases, we reanalyzed the strength of association between BC incidence rates in 180 countries worldwide and ALAN, controlling for several country-level predictors, including birth rates, percent of urban population, per capita GDP and electricity consumption. We also compared BC age-standardized rates (ASRs) with multi-annual ALAN measurements, considering potentially different latency periods. Compared with the results of Kloog et al.'s analysis of the year-2002 BC-data, the association between BC and ALAN appears to have weakened overall, becoming statistically insignificant in the year 2012 after being controlled for potential confounders (t < 0.3; p > 0.5). However, when the entire sample of countries was disaggregated into geographic clusters of similarly developed countries, a positive BC-ALAN association re-emerged as statistically significant (t > 2.2; p < 0.01), helping to explain, along with other factors covered by the analysis, about 65-85% of BC ASR variability worldwide, depending on the model type. Although the present analysis reconfirms a positive BC-ALAN association, this association appeared to diverge regionally in recent years, with countries in Western Europe showing the highest levels of such association, while countries in Southeast Asia and Gulf States exhibiting relatively low BC rates against the backdrop of relatively high ALAN levels. This regional stratification may be due to additional protective mechanisms, diminishing BC risks and potentially attributed to the local diet and lifestyles.

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Artificial Light at Night (ALAN) and breast cancer incidence worldwide: A revisit of earlier findings with analysis of current trends

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