Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study)

Apr 25, 2018Environmental health perspectives

Artificial Light at Night and Its Link to Breast and Prostate Cancer Risk in Spain

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Abstract

Exposure to outdoor artificial light at night (ALAN) in the blue light spectrum is associated with a 1.47 times higher risk of breast cancer and a 2.05 times higher risk of prostate cancer.

Participants exposed to the highest levels of outdoor ALAN had a greater likelihood of developing breast cancer compared to those with the lowest exposure.
A significant association was observed between higher outdoor ALAN exposure and increased risk of prostate cancer.
Men sleeping in bedrooms with considerable illumination had a higher risk of prostate cancer compared to those sleeping in total darkness.
In contrast, women exposed to illuminated bedrooms exhibited a slightly lower risk of breast cancer compared to those in complete darkness.
The study was conducted in a multicase-control framework involving 1,219 breast cancer cases and 623 prostate cancer cases across 11 Spanish regions.

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BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers.

OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night.

METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013. Indoor ALAN information was obtained through questionnaires. Outdoor ALAN was analyzed using images from the International Space Station (ISS) available for Barcelona and Madrid for 2012-2013, including data of remotely sensed upward light intensity and blue light spectrum information for each geocoded longest residence of each MCC-Spain subject.

RESULTS: Among Barcelona and Madrid participants with information on both indoor and outdoor ALAN, exposure to outdoor ALAN in the blue light spectrum was associated with breast cancer [adjusted odds ratio (OR) for highest vs. lowest tertile, OR=1.47; 95% CI: 1.00, 2.17] and prostate cancer (OR=2.05; 95% CI: 1.38, 3.03). In contrast, those exposed to the highest versus lowest intensity of outdoor ALAN were more likely to be controls than cases, particularly for prostate cancer. Compared with those who reported sleeping in total darkness, men who slept in "quite illuminated" bedrooms had a higher risk of prostate cancer (OR=2.79; 95% CI: 1.55, 5.04), whereas women had a slightly lower risk of breast cancer (OR=0.77; 95% CI: 0.39, 1.51).

CONCLUSION: Both prostate and breast cancer were associated with high estimated exposure to outdoor ALAN in the blue-enriched light spectrum. https://doi.org/10.1289/EHP1837.

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Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study)

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