Aryl hydrocarbon receptor affects circadian-regulated lipolysis through an E-Box-dependent mechanism

Activation of the aryl hydrocarbon receptor (AhR) significantly dampens the rhythmic expression of key metabolic genes in adipose tissue.

• AhR activation is associated with reduced expression of core clock and lipolysis genes in mouse adipocytes.
• Changes in gene expression patterns may lead to impaired lipolysis during fasting.
• Decreased lipolysis is linked to altered serum concentrations of free fatty acids and glycerol.
• Increased binding of AhR to specific gene promoters suggests a direct mechanism of action.
• Impaired lipolysis may trigger compensatory increases in glycogen breakdown to maintain energy levels.

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