Increasing AS160 Protects Insulin-Producing Cells in High Blood Sugar Mice by Working with HSPA8 to Control Mitochondrial Cleanup

Insulin deficiency from pancreatic beta-cell loss is central to the development of type 1 and type 2 diabetes.

• AS160 may play a role in managing mitochondrial balance and insulin release in pancreatic beta-cells.
• The interaction between AS160 and HSPA8 is involved in the regulation of these processes.
• Activation of PINK1-Parkin-mediated mitophagy could be a critical mechanism in this context.

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