Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students

Jun 3, 2014Journal of physiological anthropology

Link between a light-sensitive gene variant and sleep timing in Japanese university students

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

In a study of 348 healthy Japanese university students, the CC genotype was associated with significantly later sleep/wake timing compared to the TT and TC genotypes.

No significant differences in circadian preference were observed among the genotype groups.
On weekdays, CC subjects had significantly later bedtimes, wake times, and midpoints of sleep than TT and TC subjects.
During weekends, CC subjects went to bed significantly later than both TT and TC subjects.
The midpoint of sleep for CC subjects was also significantly later than that of TC subjects on weekends.

AI simplified

BACKGROUND: In our previous studies, we found that the Ile394Thr SNP in the melanopsin gene (OPN4) was functionally associated with the pupillary light reflex. This indicates the possibility that OPN4Ile394Thr is associated with other non-image forming responses. The aim of this study was therefore to determine whether OPN4Ile394Thr is associated with sleep/wake timing.

METHODS: A total of 348 healthy Japanese university students participated in this study. Scalp hair was used to genotype the Ile394Thr SNP of OPN4. Sleep habits, including bedtime, wake time and sleep duration, were assessed separately for weekdays and weekends. A total of 328 samples, including 223 samples with TT genotype, 91 with TC genotype and 14 with CC genotype, were used for statistical analysis. No significant difference in age or male/female distribution was found among the three genotype groups.

RESULTS: There was no significant difference in circadian preference among the genotype groups. During weekdays, bedtime, wake time and midpoint of sleep for CC subjects were significantly later than those for TT and TC subjects. However, there was no difference between TT and TC subjects in any of their sleep habits. During weekends, bedtime of CC subjects was significantly later than those of TT and TC subjects, and the midpoint of sleep of CC subjects was significantly later than that of TC subjects.

CONCLUSIONS: Our findings demonstrated that OPN4*Ile394Thr is associated with sleep/wake timing. We also found that the sleep/wake timing of subjects with the CC genotype was later than that of subjects with the TT or TC genotype.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (PDF) ↗

Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief