Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1

📖 Top 30% JournalJan 17, 2015Molecular medicine reports

Astragaloside IV helps prevent collagen loss in sun-damaged skin by boosting growth factor signals and blocking collagen-breaking enzymes

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Abstract

Topical application of Astragaloside IV (AST) reversed collagen reduction in human skin fibroblasts exposed to UV light.

UV light exposure leads to reduced levels of type I collagen and promotes skin aging.
Increased expression of matrix metalloproteinase-1 (MMP-1) contributes to collagen degradation following UV irradiation.
The TGF-β/Smad signaling pathway is suppressed by UV exposure, resulting in decreased collagen production.
Application of AST was associated with improved TGF-β/Smad signaling and reduced MMP-1 levels.
AST may serve as a potential agent to counteract skin damage associated with photoaging.

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Exposure to ultraviolet (UV) light reduces levels of type I collagen in the dermis and results in human skin damage and premature skin aging (photoaging). This leads to a wrinkled appearance through the inhibition of transforming growth factor‑β (TGF‑β)/Smad signaling. UV irradiation increases type I collagen degradation through upregulating matrix metalloproteinase (MMP) expression. Astragaloside IV (AST) is one of the major active components extracted from Astragalus membranaceus. However, its multiple anti‑photoaging effects remain to be elucidated. In the present study, the effects of AST against collagen reduction in UV‑induced skin aging in human skin fibroblasts were investigated. The expression of type I procollagen (COL1), MMP‑1, TGF‑βRⅡ and Smad7 were determined using reverse transcription‑polymerase chain reaction, western blotting and ELISA, respectively. UV irradiation inhibits type I collagen production by suppressing the TGF‑β/Smad signaling pathway and increasing COL1 degradation by inducing MMP‑1 expression. Transforming growth factor‑β type II protein and COL1 mRNA decreased but MMP‑1 and Smad7 levels increased in the photoaging model group, which was reversed by topical application of AST. AST prevents collagen reduction from UV irradiation in photoaging skin by improving TGF‑β/Smad signaling suppression and inhibiting MMP‑1, thus AST may be a potential agent against skin photoaging.

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