Eucalyptus globulus extract protects against UVB-induced photoaging by enhancing collagen synthesis via regulation of TGF-β/Smad signals and attenuation of AP-1

📖 Top 20% JournalNov 21, 2017Archives of biochemistry and biophysics

Eucalyptus extract may protect skin from UVB aging by boosting collagen through TGF-beta signals and reducing AP-1 activity

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Abstract

Eucalyptus globulus reduced wrinkle formation and dryness in UVB-irradiated hairless mice.

UV irradiation leads to overproduction of matrix metalloproteinases and collagen degradation, contributing to photoaging symptoms.
Eucalyptus globulus extracts suppressed the expression of matrix metalloproteinases and interleukin-6 in treated dermal fibroblasts.
The extracts increased the expression of transforming growth factor-beta1 and procollagen type 1, which are associated with collagen production.
Eucalyptus globulus inhibited the activation of the AP-1 transcription factor, which is known to induce matrix metalloproteinases.
In vivo application resulted in reduced wrinkle formation and dryness, indicating a potential protective effect against photoaging.

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UV irradiation triggers the overproduction of matrix metalloproteinases and collagen degradation, which in turn causes increased pigmentation, dryness, and deep wrinkling of the skin. These chronic symptoms are collectively referred to as photoaging. Eucalyptus globulus is an evergreen tree that is widely used in cosmetics because of its antimicrobial activity. In this study, we investigated the protective effect of 50% ethanol extracts of Eucalyptus globulus on UV-induced photoaging in vitro and in vivo. Normal human dermal fibroblasts were treated with Eucalyptus globulus at concentrations ranging from 1 to 100 μg/mL after UVB or non-UVB irradiation. We found that Eucalyptus globulus suppressed the expression of MMPs and IL-6, but increased the expression of TGF-β1 and procollagen type 1. In addition, Eucalyptus globulus inhibited activation of the AP-1 transcription factor, an inducer of MMPs. Eucalyptus globulus was also found to regulate TGF-β/Smad signaling by reversing the activity of negative Smad regulators. Lastly, in vivo studies showed that topical application of Eucalyptus globulus on UVB-irradiated hairless mice reduced wrinkle formation and dryness by down-regulating MMP-1 and up-regulating expression of elastin, TGF-β1, and procollagen type 1. Taken together, these data suggest that Eucalyptus globulus may be a useful agent in cosmetic products.

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