Eucalyptus extract may protect skin from UVB aging by boosting collagen through TGF-beta signals and reducing AP-1 activity

Eucalyptus globulus reduced wrinkle formation and dryness in UVB-irradiated hairless mice.

• UV irradiation leads to overproduction of matrix metalloproteinases and collagen degradation, contributing to photoaging symptoms.
• Eucalyptus globulus extracts suppressed the expression of matrix metalloproteinases and interleukin-6 in treated dermal fibroblasts.
• The extracts increased the expression of transforming growth factor-beta1 and procollagen type 1, which are associated with collagen production.
• Eucalyptus globulus inhibited the activation of the AP-1 transcription factor, which is known to induce matrix metalloproteinases.
• In vivo application resulted in reduced wrinkle formation and dryness, indicating a potential protective effect against photoaging.

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