Astrocyte SIRT3 may reduce brain inflammation after stroke by blocking the cGAS-STING pathway

Sirtuin 3 (SIRT3) expression is significantly suppressed post-injury in ischemic stroke models.

• Inhibition of SIRT3 post-stroke is linked to increased activation of the cGAS-STING signaling pathway.
• Elevated levels of pro-inflammatory cytokines are observed following ischemic injury.
• Pharmacological activation or genetic overexpression of SIRT3 reduces cerebral damage and improves neurological outcomes.
• Targeted knockdown of cGAS or STING leads to decreased inflammatory responses.
• SIRT3 overexpression modifies gene expression related to DNA sensing and innate immune responses.

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