Weakened daily body clock rhythms in mice without the prokineticin 2 gene

PK2-null mice exhibited significantly reduced rhythmicity across various physiological and behavioral parameters.

• Locomotor rhythms were diminished in PK2-null mice regardless of genetic background.
• Sleep-wake cycles, body temperature, and levels of glucocorticoids and glucose were also notably affected.
• The expression of peripheral clock genes was significantly reduced in PK2-null mice.
• PK2-null mice displayed faster acquisition of food anticipatory behavior during daytime food restriction.
• These findings suggest that PK2 may be vital for maintaining robust circadian rhythms.

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