Atypical antipsychotics: revolutionary or incremental advance?

Clozapine was introduced in the USA specifically for treatment-refractory schizophrenia.

• First generation antipsychotics often reduced positive symptoms but were less effective for negative symptoms, cognitive impairment, and aggression.
• Clozapine, as a second generation antipsychotic, was developed to address treatment-resistant cases of schizophrenia.
• The side effects of clozapine have prompted the search for alternative treatments.
• A variety of second generation antipsychotics has emerged, raising expectations for treatment options.
• Atypical antipsychotics may also be beneficial for nonpsychotic patients experiencing mood dysregulation or acute agitation.

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