How Disordered Proteins Help Clear Cell Waste Without Membranes and Inside Membrane Compartments

Microautophagy is an extremely LLPS-friendly pathway.

• Autophagy relies on the process of liquid-liquid phase separation (LLPS).
• Parameters indicate the plasticity of autophagy proteins in relation to LLPS.
• Several mechanisms involve autophagy proteins driving LLPS on different membrane types.
• Factors that modulate the LLPS potential of autophagy proteins are summarized.
• The findings suggest a high probability for autophagy-related proteins to undergo spontaneous LLPS.

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