Autophagy in proteostasis and aging in Caenorhabditis elegans

Autophagy is central to maintaining proteostasis, the balance of protein synthesis, folding, and degradation.

• Disruption of proteostasis leads to the buildup of misfolded proteins, which is linked to aging and neurodegenerative diseases.
• In the model organism Caenorhabditis elegans, autophagy has been shown to help maintain proteostasis during aging and stress.
• Autophagy not only degrades toxic proteins but also assists in forming protective protein inclusions.
• There is a collaboration between autophagy and the ubiquitin-proteasome system in managing protein quality.
• New findings suggest that autophagy may also involve nontraditional pathways like unconventional secretion and communication between tissues.

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