Full text is available at the source.
Abstract
Phase separation may provide a crucial framework for autophagy, enabling targeted degradation of cellular macromolecules.
- Biomolecular condensates formed by phase separation can enhance binding between autophagy receptors and cargo.
- These condensates may specify cargo selection and initiate autophagosome formation at specific locations within the cell.
- The physical properties of condensates, such as wetting, could influence how they interact with membranes and affect engulfment efficiency.
- Understanding autophagy through the perspective of condensate physics may reveal new therapeutic opportunities.
Simplified