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Abstract
Autophagy and cellular senescence are linked processes that significantly impact kidney health during aging and disease.
- Autophagy helps maintain cellular integrity by breaking down damaged components and waste, which is crucial for energy balance.
- A decline in autophagic activity with age or stress may lead to an accumulation of senescent cells and chronic inflammation.
- In the kidneys, this imbalance is associated with the development of chronic kidney disease (CKD) and acute kidney injury (AKI).
- Senescent cells can produce substances that increase inflammation, fibrosis, and tissue changes, worsening kidney conditions.
- The interaction between reduced autophagy and increased senescence may accelerate kidney damage and hinder recovery after injury.
- New treatment options, such as autophagy enhancers and senolytics, are being explored to improve kidney function and counteract aging effects.
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