changes after low-level red-light therapy showed a significant difference over 24 months (F = 16.12, P < 0.001).
The amount of axial length change was significant at the 6-month follow-up, with a mean change of △AL = -0.16 ± 0.18.
Longer baseline axial length and higher spherical equivalent refractive values were positively correlated with changes in axial length.
Children with high myopia experienced greater axial regression compared to those with mild and moderate myopia.
Age was positively correlated with changes in axial length.
Combination with other myopia prevention and control measures was associated with changes in axial length at multiple follow-up points.
Baseline corneal thickness, corneal curvature, and intraocular pressure were not correlated with changes in axial length.
Simplified
BACKGROUND: To investigate the factors related to the change in after repeated low-level red-light(RLRL) therapy.
METHODS: A retrospective case study. A total of 323 children and adolescents who underwent RLRL therapy concurrently with their eye examinations at Wuhan Children's Hospital from 2022 to 2023 were included. The biological eye parameters, including the axial length (AL), spherical equivalent refractive (), the (SFCT), intraocular pressure (IOP), corneal curvature and corneal thickness, were recorded at baseline, 3-month, 6-month, 12-month, 12-month, 18-month and 24-month. The factors related to the degree of change in axial length were analyzed.
RESULTS: There was a statistical difference in the amount of AL changes during the follow-up (F = 16.12, P < 0.001), and the amount of AL changes was significant at the 6-month follow-up (△AL=-0.16 ± 0.18), and then gradually decreased with the extension of follow-up time. There was a statistically positive correlation between baseline AL and baseline SER and changes in AL (P < 0.05). The axial regression in high myopia group was significantly greater than that in mild and moderate myopia group (P < 0.05). There was also a statistically positive correlation between age and changes in AL (P < 0.05). At the follow-up of 6 months, 12 months, 18 months, combined with other myopia prevention and control was correlated with the change of AL (P < 0.05). Baseline corneal thickness, baseline corneal curvature and baseline IOP were not correlated with changes in AL (all P > 0.05).
CONCLUSION: The longer the baseline AL, the higher SER, the thinner SFCT, the older the age and the combination of other myopia prevention and control measures, the more obvious the change of AL. However, the changes of AL were not affected by IOP, corneal curvature and corneal thickness.
Key numbers
−0.16 ± 0.18 mm
Change
Change in from baseline after RLRL therapy.
323 children and adolescents
Sample Size
Total participants treated with RLRL therapy.
24.79 ± 1.08 mm
Baseline
Average before RLRL therapy.
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Declarations. Ethics approval and consent to participate: This research was approved by the Ethics Committee of Wuhan Children’s Hospital (20211126-E04, 20211126-E05) and all relevant principles of the Declaration of Helsinki were followed. All eligible patients who were willing to participate signed informed consent from approved by an institutional review board. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
