Do bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis

Sep 18, 2017Neuroscience and biobehavioral reviews

Do gut bacteria influence our development? Communication between gut microbes and the body's stress system

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Abstract

The human intestine houses as many bacteria as there are human body cells.

  • Intestinal bacteria may influence human health, emotions, behavior, and cognitive functions.
  • The HPA axis is a key system that regulates stress responses and brain development.
  • Both the HPA axis and intestinal microbiota undergo significant changes during early life.
  • Early environmental disturbances could disrupt the development of both the HPA axis and gut bacteria.
  • Early adversity is associated with imbalances in these systems and may lead to emotional and behavioral issues.

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