Bacterial enzymes that change bile salts and their possible role in gut microbe and host communication

Elevated microbial bile salt hydrolase (BSH) activity is associated with significant alterations in host functions related to lipid metabolism and weight gain.

• BSH activity leads to local bile acid deconjugation in the gastrointestinal tract.
• Changes in lipid and cholesterol metabolism are observed with increased BSH expression.
• Key factors involved in cholesterol balance and gut health are influenced by elevated BSH.
• The findings suggest a potential link between gut microbiota activity and host weight gain.

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