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Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk
Bacterial enzymes that change bile salts and their possible role in gut microbe and host communication
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Abstract
Elevated microbial bile salt hydrolase (BSH) activity is associated with significant alterations in host functions related to lipid metabolism and weight gain.
- BSH activity leads to local bile acid deconjugation in the gastrointestinal tract.
- Changes in lipid and cholesterol metabolism are observed with increased BSH expression.
- Key factors involved in cholesterol balance and gut health are influenced by elevated BSH.
- The findings suggest a potential link between gut microbiota activity and host weight gain.
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