Journal of pharmaceutical and biomedical analysisMay 29, 2024

How Banxia Baizhu Tianma Decoction may improve dizziness from reduced blood flow in the back brain by linking gut fatty acids and bacteria

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 1, 2026

Abstract

BBTD administration effectively reduced the volume of cerebral infarction and improved neurologic functions in a rat model of posterior circulation ischemia vertigo.

BBTD treatment decreased neuronal cell death and neuroinflammation.
Significant changes in gut microbiota diversity and composition were observed, including an increase in beneficial bacteria such as Lactobacillus and Prevotella.
Relative abundances of harmful bacteria like Lachnospiraceae and Bacteroidetes were reduced following BBTD treatment.
BBTD administration increased the content of propionate, a short-chain fatty acid associated with neurological recovery.
Propionate may play a role in enhancing neurological functions and reducing apoptosis in the context of PCIV.

Simplified

Posterior circulation ischemia vertigo (PCIV) is vertebrobasilar insufficiency resulting in vertigo. Banxia Baizhu Tianma Decoction (BBTD) is broadly applied to treat PCIV in China, but its efficacy and detailed mechanism remains unclear. Therefore, this study aims to investigate the effects of BBTD on PCIV, and identify important gut microbiota and its derived short-chain fatty acid (SCFA) changes and the detailed mechanism through 16 S rRNA sequencing with SCFAs profiling. In this study, the model of PCIV was established by surgical ligation of the right subclavian artery (RSCA) and right common carotid artery (RCCA). We found that BBTD administration effectively reduced the volume of cerebral infarction and improved neurologic functions, reduced neuronal apoptosis and neuroinflammatory. Moreover, BBTD significantly modulated the diversity and composition of the gut microbiota, including increasing the relative abundance of Lactobacillus, Prevotella and Akkermansia and decreasing relative abundances of Lachnospiraceae, Bacteroidetes (S24-7) and Ruminococcaceae. BBTD treatment also increased propionate content. Propionate mediates the the recovery of neurological functions and anti-apoptotic effects of BBTD in PCIV rat. Our findings wish to discover the potential mechanism of BBTD treatment on PCIV and promote its clinical application.

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Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

PubMed

How Banxia Baizhu Tianma Decoction may improve dizziness from reduced blood flow in the back brain by linking gut fatty acids and bacteria

Abstract

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Competing interests

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Abstract

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