Journal of human immunitySep 3, 2026

Using base editing to reduce radiation sensitivity in people with NHEJ1-related DNA repair problems

CRISPR Gene Editing Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Sep 4, 2026

Abstract

Base editing was applied to reverse NHEJ1 mutations in patient fibroblasts.

Inherited defects in DNA double-stranded break repair may lead to radiosensitive SCID.
NHEJ1 mutations are associated with this condition.
Base editing demonstrates potential for studying radiosensitive sequence variants.

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